2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Heme oxygenase (HO)

Heme oxygenase (HO)

Heme oxygenase

Heme oxygenase (HO) is an enzyme that catalyzes the degradation of heme to produce biliverdin/bilirubin, ferrous iron and carbon monoxide. Heme oxygenase (HO) can be divided into inducible type (HO-1) and constitutive type (HO-2). HO-1 is a kind of heat shock protein 32 (HSP32). Its expression level is low in normal physiological state, but it will increase significantly when induced by various stimuli such as oxidative stress, heavy metals, and inflammatory factors. HO-2 is continuously and stably expressed in brain, testis and other tissues, and is involved in maintaining the normal physiological function of cells. Heme oxygenase (HO) plays a key role in cell stress response and homeostasis, and the dysregulation of its expression or activity is related to the pathophysiology of cardiovascular disease, diabetes, obesity, lung disease, gastrointestinal disease, renal dysfunction, dermatitis, cancer and other diseases[1].

Heme oxygenase (HO) Isoform Specific Products:

Heme oxygenase (HO) Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-118487
    OB-24
    		Inhibitor 98.03%
    OB-24 is a potent inhibitor of heme oxygenase-1 (HO-1). Heme oxygenase-1, a member of the heat shock protein family, plays a key role as a sensor and regulator of oxidative stress. OB-24 significantly inhibited cell proliferation in vitro and tumor growth and lymph node/lung metastases in vivo. OB-24 has potential for the research of advanced prostate cancer (PCA).
    OB-24
  • HY-W010320
    Ethyl maltol
    		99.97%
    Ethyl maltol (2-Ethyl-3-hydroxy-4H-pyran-4-one) is an orally active and important food additive and flavor enhancer. Ethyl maltol is less toxic to rats and dogs. Ethyl maltol can enhance copper-mediated cytotoxicity and induce apoptosis in lung epithelial cells.
    Ethyl maltol
  • HY-167874
    ASP-8731
    ASP8731 is a selective inhibitor of BACH1. ASP8731 inhibits inflammation and vaso-occlusion and induces fetal hemoglobin in sickle cell disease.
    ASP-8731
  • HY-136476B
    Cu(II) protoporphyrin IX
    		Control
    Cu (II) Protoporphyrin IX is used as a negative control for Zn (II) Protoporphyrin (an inihibitor of heme oxygenase). Heme oxygenase has been implicated in tumor cell resistance to chemotherapy, reduction of free radical formation and inflammation, and associated with vascular repair.
    Cu(II) protoporphyrin IX
  • HY-170904
    NLRP3-IN-72
    		Inducer
    NLRP3-IN-72 (Compound 2) is a benzimidazole derivative. NLRP3-IN-72 exhibits anti-inflammatory and antioxidant activities. NLRP3-IN-72 has an IC50 of 0.3 μM for NLRP3 IL-1β, a PD50 of 0.4 μM for protecting against pyroptosis, and an EC50 of 0.6 μM for inducing HO-1.
    NLRP3-IN-72
  • HY-W424839
    Probucol dithiobisphenol
    		Inducer
    Probucol dithiobisphenol (DTBP) is the derivative of Probucol (HY-B0388). Probucol dithiobisphenol induces the production of heme oxygenase 1 (HO-1), and exhibits antioxidant activity. Probucol dithiobisphenol inhibits atherosclerotic lesions in ApoE−/− mice aorta, promotes re-endothelialization of aorta and inhibits restenosis in rabbit arterial injury models. Probucol dithiobisphenol is orally active.
    Probucol dithiobisphenol
  • HY-162857
    Heme Oxygenase-1-IN-3
    		Inhibitor
    Heme Oxygenase-1-IN-3 (compound 4) is a highly selective heme oxygenase-1 (HO-1) inhibitor (Kd=141 nM) that can be used in the research of cancer and neurodegenerative diseases.
    Heme Oxygenase-1-IN-3
  • HY-170867
    Nrf2/HO-1 activator 3
    		Inhibitor
    Nrf2/HO-1 activator 3 (Compound C3a) is the activator for Nrf2 signaling pathway that promotes the Nrf2 translocation into nuclei and upregulates the expression of heme oxygenase-1 HO-1. Nrf2/HO-1 activator 3 inhibits the overespression of ROS and MDA in H2O2- or glucose-stimulated H9c2 cardiomyocytes, inhibits the cell viability and colony formation, thereby exhibiting antioxidant efficacy.
    Nrf2/HO-1 activator 3
  • HY-W010320R
    Ethyl maltol (Standard)
    Ethyl maltol (Standard) is the analytical standard of Ethyl maltol. This product is intended for research and analytical applications. Ethyl maltol (2-Ethyl-3-hydroxy-4H-pyran-4-one) is an orally active and important food additive and flavor enhancer. Ethyl maltol is less toxic to rats and dogs. Ethyl maltol can enhance copper-mediated cytotoxicity and induce apoptosis in lung epithelial cells.
    Ethyl maltol (Standard)
  • HY-108922
    Probucol disuccinate
    		99.14%
    Probucol Disuccinate is a derivative of Probucol, a lipid-regulating agent and can reduce LDL-cholesterol levels.
    Probucol disuccinate
Heme oxygenase (HO) Isoform Comparison

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